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KMID : 0043320140370040467
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Archives of Pharmacal Research
2014 Volume.37 No. 4 p.467 ~ p.472
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A new neolignan and lignans from the stems of Lindera obtusiloba Blume and their anti-allergic inflammatory effects
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Choi Hyun-Gyu
Choi Yeon-Ho
Kim Ji-Hyang
Kim Hui-Hun
Kim Sang-Hyun
Kim Jeong-Ah
Lee Sang-Myung
Na Min-Kyun
Lee Seung-Ho
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Abstract
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A new neolignan, linderin A (1), together with six known lignans, (+)-xanthoxyol (2), pluviatilol (3), actiforin (4), (+)-syringaresinol (5), (+)-(7S,8R,8′R)-acuminatolide (6), and (+)-9′-O-trans-feruloyl-5,5′-dimethoxylariciresinol (7) were isolated from the stems of Lindera obtusiloba Blume (Lauraceae). Their chemical structures were elucidated by a combination of spectroscopic analysis and chemical reaction, and the absolute configuration of 1 was determined by Mosher’s esterification. The effect of compounds 1?7 on tumor necrosis factor (TNF)-α, interleukin(IL)-6, and their inhibitory activity of histamine release were examined using human mast cells. Among the lignans tested, compounds 1, 3, 4, 6, and 7 inhibited release of histamine from mast cells. Especially, compounds 1 and 4 suppressed the gene expressions of pro-inflammatory cytokines, TNF-α, and IL-6 in human mast cells. Our findings suggest that the lignan constituents in L. obtusiloba may contribute to its anti-allergic inflammatory effects.
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KEYWORD
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Lindera obtusiloba, Lignan, Linderin A, Anti-allergic effect
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